Metabolic improvement in obese patients after duodenal–jejunal exclusion is associated with intestinal microbiota composition changes
| Autor: | C. de Jonge, W.M. de Vos, R. Nelissen, Nicole D. Bouvy, Erwin G. Zoetendal, WA Buurman, Jan Greve, Susana Fuentes, Sander S. Rensen |
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| Přispěvatelé: | MUMC+: MA AIOS Heelkunde (9), Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
BACTERIAL Endocrinology Diabetes and Metabolism Veillonella Medicine (miscellaneous) WEIGHT-LOSS GASTRIC BYPASS 030209 endocrinology & metabolism Type 2 diabetes Gastroenterology Microbiology DIET 03 medical and health sciences 0302 clinical medicine INFLAMMATION Weight loss RICHNESS Microbiologie Internal medicine Lactobacillus Diabetes mellitus medicine Life Science 030212 general & internal medicine MolEco Feces VLAG Nutrition and Dietetics biology BIFIDOBACTERIUM-ANIMALIS business.industry INSULIN SENSITIVITY biology.organism_classification medicine.disease Obesity Small intestine medicine.anatomical_structure HUMAN GUT MICROBIOTA medicine.symptom business LACTOBACILLUS-REUTERI |
| Zdroj: | International Journal of Obesity, 43, 2509-2517 International Journal of Obesity 43 (2019) International Journal of Obesity, 43(12), 2509-2517. Nature Publishing Group |
| ISSN: | 0307-0565 |
| Popis: | Background Intestinal microbiota have been suggested to play an important role in the pathogenesis of obesity and type 2 diabetes. Bariatric surgery improves both conditions and has been associated with changes in intestinal microbiota composition. We investigated the effect of a nonsurgical bariatric technique on intestinal microbiota composition in relation to metabolic improvement.Methods Seventeen patients with obesity and type 2 diabetes were treated with the nonsurgical duodenal-jejunal bypass liner, which excludes the proximal 60 cm small intestine from food. Fecal samples as well as metabolic parameters reflecting obesity and type 2 diabetes were obtained from the patients at baseline, after 6 months with the device in situ, and 6 months after explantation.Results After 6 months of treatment, both obesity and type 2 diabetes had improved with a decrease in weight from 106.1 [99.4-123.5] to 97.4 [89.4-114.0] kg and a decrease in HbA(1c) from 8.5% [7.6-9.2] to 7.2% [6.3-8.1] (both p Conclusion Improvement of obesity and type 2 diabetes after exclusion of the proximal 60 cm small intestine by treatment with a nonsurgical duodenal-jejunal bypass liner may be promoted by changes in fecal microbiota composition. |
| Databáze: | OpenAIRE |
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