A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
| Autor: | Barba, Christophe, Benoit, Bérengère, Bres, Emilie, Chanon, Stéphanie, Vieille-Marchiset, Aurélie, Pinteur, Claudie, Pesenti, Sandra, Glorieux, Griet, Picard, Cécile, Fouque, Denis, Soulage, Christophe O., Koppe, Laetitia |
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| Přispěvatelé: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Ghent University Hospital, ROSSI, Sabine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
030309 nutrition & dietetics P-CRESYL SULFATE Science 030209 endocrinology & metabolism Kidney GLOMERULAR-FILTRATION-RATE Article MECHANISMS Amino Acids Aromatic Mice 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Diet Protein-Restricted Medicine and Health Sciences Animals Humans Uremic Toxins Renal Insufficiency Chronic 2. Zero hunger DAMAGE 0303 health sciences Kidney diseases Malnutrition GUT MICROBIOTA LOW-PROTEIN DIET Fibrosis 3. Good health Disease Models Animal [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition MAMMALIAN TARGET Nephrology Medicine [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.19184. ⟨10.1038/s41598-021-98718-x⟩ Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Scientific Reports, 2021, 11 (1), pp.19184. ⟨10.1038/s41598-021-98718-x⟩ SCIENTIFIC REPORTS |
| ISSN: | 2045-2322 |
| Popis: | International audience; Abstract Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS). We hypothesize that a low aromatic amino acid diet (LA-AAD, namely a low intake of tyrosine, tryptophan and phenylalanine) while being normoproteic, could be as effective as a LPD, through the decreased production of uremic toxins. Kidney failure was chemically induced in mice with a diet containing 0.25% (w/w) of adenine. Mice received three different diets for six weeks: normoproteic diet (NPD: 14.7% proteins, aromatic AAs 0.019%), LPD (5% proteins, aromatic AAs 0.007%) and LA-AAD (14% proteins, aromatic AAs 0.007%). Both LPD and LA-AAD significantly reduced proteinuria, kidney fibrosis and inflammation. While LPD only slightly decreased plasma free PCS and free IS compared to NPD; free fractions of both compounds were significantly decreased by LA-AAD. These results suggest that a LA-AAD confers similar benefits of a LPD in delaying the progression of CKD through a reduction in some key uremic toxins production (such as PCS and IS), with a lower risk of malnutrition. |
| Databáze: | OpenAIRE |
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