Radiopharmaceutical for detecting PSMA — positive metastatic colon cancer: Matched-pair comparison of 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI

Autor:	Omer, Aras, Cetin, Demirdag, Harikrishna, Kommidi, Richard, Ting, Haluk B, Sayman
Rok vydání:	2022
Předmět:	Male Prostatic Neoplasms Gallium Radioisotopes General Medicine Magnetic Resonance Imaging Article Glutarates Positron Emission Tomography Computed Tomography Positron-Emission Tomography Colonic Neoplasms Humans Radiology Nuclear Medicine and imaging Radiopharmaceuticals Gallium Isotopes
Zdroj:	Nucl Med Rev Cent East Eur
ISSN:	1644-4345 1506-9680
Popis:	Prostate-specific membrane antigen (PSMA) - based radiopharmaceuticals are promising for the evaluation of PSMA-positive non-prostate cancers. In this case study, 18F-BF3-Cy3-ACUPA and 68Ga-PSMA positron emission tomography/magnetic resonance imaging (PET/MRI) were compared in a patient with metastatic colon cancer. Both 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI showed biopsy-proven metastatic left external iliac adenopathy, highlighting the feasibility of PSMA uptake in PET/MRI of metastatic nodal disease from colon cancer. Along with imaging evaluation, PSMA-based radiopharmaceuticals may also be used as a surrogate imaging tracer for potential theranostic applications using alpha or beta emitters in the context of PSMA-directed radiopharmaceutical therapy in advanced and progressive colorectal cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5d262d6356cc2217a245008088e804 https://doi.org/10.5603/nmr.a2022.0027 Zobrazit plný text záznamu