Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats
| Autor: | Robert C. Fowkes, Jonathan Elliott, Victoria J Crossley, Yu-Mei Chang, H.M. Syme, A. Debnath |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Coat medicine.medical_specialty endocrine system diseases 040301 veterinary sciences Physiology Standard Article Disease Cat Diseases Hyperthyroidism 0403 veterinary science 03 medical and health sciences Endocrinology Species Specificity Risk Factors Internal medicine Epidemiology medicine Animals Animal Fur Hair Color Retrospective Studies CATS General Veterinary business.industry Thyroid Cat Bayes Theorem 04 agricultural and veterinary sciences Odds ratio Standard Articles Breed Cross-Sectional Studies Phenotype 030104 developmental biology medicine.anatomical_structure Pigment Cats Tyrosine Tyrosinase Female SMALL ANIMAL business Hormone |
| Zdroj: | Journal of Veterinary Internal Medicine |
| ISSN: | 0891-6640 |
| Popis: | Background Hyperthyroidism is very common in older cats, but the etiopathogenesis is poorly understood. Decreased risk of hyperthyroidism has been reported in certain colorpoint breeds, and this observation previously has been hypothesized to result from relatively greater tyrosine availability for thyroid hormone production because of limited ability to convert tyrosine to melanin pigment. However, studies investigating a potential link between coat pigmentation and risk of hyperthyroidism are limited. Objective To identify associations between coat phenotype and hyperthyroidism by investigation of breed, coat color, and hair length as risk factors for the disease. Animals Data were used from 4,705 cats aged ≥10 years, referred to a single veterinary teaching hospital (2006–2014) in the United Kingdom. Methods Retrospective, epidemiological, cross-sectional study using Bayesian multivariable logistic regression to assess risk factors for hyperthyroidism. Results Burmese (odds ratio [OR], 0.01; 0.00–0.23; P = .004), Tonkinese (OR, 0.05; 0.00–0.95; P = .046), Persian (OR, 0.21; 0.10–0.44; P < .001), Siamese (OR, 0.27; 0.12–0.61; P = .002), Abyssinian (OR, 0.04; 0.00–0.74; P = .031), and British shorthair (OR, 0.47; 0.28–0.79; P = .004) breeds had decreased risk of hyperthyroidism compared to domestic shorthairs. Longhaired, nonpurebred cats (OR, 1.30; 1.03–1.64; P = .028) were at increased risk of hyperthyroidism. Coat color/pattern was not associated with hyperthyroidism in nonpurebred cats. Conclusions and Clinical Importance We identified decreased risk of hyperthyroidism in the Tonkinese, Abyssinian, and British shorthair breeds, identified an association between risk of hyperthyroidism and hair length, and confirmed decreased risk in Burmese, Siamese, and Persian breeds. Additional studies are warranted to further investigate these findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text