EFFECT OF INSULIN INDUCED HYPOGLYCAEMIA ON THE BLOOD LEVELS OF CATECHOLAMINES, GLUCAGON, GROWTH HORMONE, CORTISOL, C-PEPTIDE AND PROINSULIN BEFORE AND DURING MEDICATION WITH THE CARDIOSELECTIVE BETA-RECEPTOR BLOCKING AGENT METOPROLOL IN MAN
| Autor: | Lise G. Heding, Bernt Hökfelt, Karl Olof Nilsson, Bengt-Göran Hansson |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Adrenergic receptor Endocrinology Diabetes and Metabolism Growth hormone Glucagon Propanolamines chemistry.chemical_compound Catecholamines Endocrinology Internal medicine medicine Humans Insulin Metoprolol Proinsulin Clinical Trials as Topic C-Peptide C-peptide Blocking (radio) business.industry General Medicine Middle Aged Hypoglycemia chemistry Growth Hormone Hypertension Peptides business Insulin induced hypoglycaemia hormones hormone substitutes and hormone antagonists Half-Life medicine.drug |
| Zdroj: | Acta Endocrinologica. 87:659-667 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | Studies were performed in 8 males with moderate hypertension to explore the influence of metoprolol on the sensitivity to insulin and on the response to hypoglycaemia with respect to plasma catecholamines, glucagon, growth hormone and cortisol. C-peptide and proinsulin were determined in some instances. All subjects were studied before treatment, after one month on placebo and after 3 months on metoprolol. The final maximal dose used was 50–150 mg three times daily. The sensitivity to insulin was the same during all three conditions studied. The response in catecholamines, glucagon, growth hormone and cortisol following insulin induced hypoglycaemia was similar during placebo as compared to no treatment. Adrenaline, growth hormone and cortisol showed a greater response to hypoglycaemia during metoprolol whereas no difference was seen with respect to noradrenaline and glucagon. The half-life of exogenous insulin was the same before and during metoprolol (7.6 min). Metoprolol caused no changes in the basal C-peptide levels. During the hypoglycaemic phase C-peptide showed a continuous gradual fall, which was similar before and during metoprolol. Proinsulin was below the lower limit of detection before and following the injection of insulin both without treatment and during metoprolol. |
| Databáze: | OpenAIRE |
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