Novel Water-soluble Curcumin Derivative Mediating Erectile Signaling
| Autor: | Taymour Mostafa, Amira M. Senbel, Dina Sabry, Ameen M Rezq, Laila A. Rashed, Taha A. Kumosani, Hazem Atta, Mohammed F. El Asmer, Mohamed T. Abdel Aziz, Amira Hassouna, Ahmed T. Abdel Aziz, Samya Mostafa, Mohamed A Wassef, Hanan Fouad |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Curcumin Sildenafil Urology Endocrinology Diabetes and Metabolism Administration Oral Blood Pressure Pharmacology Piperazines Sildenafil Citrate law.invention chemistry.chemical_compound Endocrinology law Oral administration medicine Animals Sulfones Cyclic GMP Cyclic guanosine monophosphate Dose-Response Relationship Drug Plant Extracts business.industry Penile Erection Rats Inbred Strains Phosphodiesterase 5 Inhibitors medicine.disease Rats Psychiatry and Mental health Dose–response relationship medicine.anatomical_structure Erectile dysfunction Reproductive Medicine chemistry Purines Cavernous tissue Delayed-Action Preparations Enzyme Induction Anesthesia Phytotherapy business Heme Oxygenase-1 Injections Intraperitoneal Penis Signal Transduction |
| Zdroj: | The Journal of Sexual Medicine. 7:2714-2722 |
| ISSN: | 1743-6095 |
| Popis: | Introduction Curcumin is an inducer of heme oxygenase enzyme-1 (HO-1) that is involved in erectile signaling via elevating cyclic guanosine monophosphate (cGMP)levels. Aim To assess the effect of oral administration of a water-soluble long-acting curcumin derivative on erectile signaling. Methods Two hundred and thirty six male white albino rats were divided into four groups; group 1 (N = 20) includes control. Group 2 (N = 72) was equally divided into four subgroups; subgroup 1 received pure curcumin (10 mg/kg), subgroup 2 received the long-acting curcumin derivative (2 mg/kg), subgroup 3 received the long-acting curcumin derivative (10 mg/kg), and subgroup 4 received sildenafil (4 mg/kg). Subgroups were sacrificed after the first, second, and third hour. Group 3 (N = 72) was equally divided into the same four subgroups already mentioned and were sacrificed after 24 hours, 48 hours, and 1 week. Group 4 (N = 72) was subjected to intracavernosal pressure (ICP) measurements 1 hour following oral administration of the same previous doses in the same rat subgroups. Main Outcome Measure Cavernous tissue HO enzyme activity, cGMP, and ICP. Results In group 2, there was a significant progressive maintained elevation of HO activity and cGMP tissue levels starting from the first hour in subgroups 3 and 4, whereas, the rise in HO activity and cGMP started from second hour regarding the other rat subgroups. Sildenafil effect decreased after 3 hours. In group 3, there was a significant maintained elevation of HO activity and cGMP tissue levels extended to 1 week as compared to controls for all rat subgroups that received both forms of curcumin. In group 4, long-acting curcumin derivative exhibited more significant potentiation of intracavernosal pressure as compared to control and to the pure curcumin. Conclusion Water-soluble long-acting curcumin derivative could mediate erectile function via upregulating cavernous tissue cGMP. Abdel Aziz MT, El Asmer MF, Rezq A, Kumosani TA, Mostafa S, Mostafa T, Atta H, Abdel Aziz Wassef M, Fouad HH, Rashed L, Sabry D, Hassouna AA, Senbel A, and Abdel Aziz A. Novel water-soluble curcumin derivative mediating erectile signaling |
| Databáze: | OpenAIRE |
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