Social jetlag and sleep deprivation are associated with altered activity in the reward-related brain areas: an exploratory resting-state fMRI study
Autor: | Ruben Nechifor, Cornelia Bala, Adriana Rusu, Georgeta Inceu, Gabriela Roman, Andreia Mocan, Dana Mihaela Ciobanu, Cristian Popita, Camelia Larisa Vonica, Anca Elena Craciun |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Brain activity and meditation Thalamus Audiology 03 medical and health sciences 0302 clinical medicine Gyrus Reward medicine Humans Brain Mapping Resting state fMRI medicine.diagnostic_test business.industry Brain General Medicine Magnetic Resonance Imaging Sleep deprivation medicine.anatomical_structure 030228 respiratory system Sleep Deprivation medicine.symptom business Functional magnetic resonance imaging Body mass index 030217 neurology & neurosurgery Brodmann area |
Zdroj: | Sleep medicine. 72 |
ISSN: | 1878-5506 |
Popis: | Objective The aim of this research was to assess the effect of social jetlag (SJL) and its interaction with partial sleep deprivation on resting-state brain activity using the fractional amplitude of low-frequency fluctuation (fALFF) during free-living conditions. Methods A total of 28 normal weight healthy subjects were enrolled in four study groups (with SJL [with sleep deprivation and without sleep deprivation] and without SJL [with sleep deprivation and without sleep deprivation]), matched 1:1:1:1 for age, gender, and body mass index (BMI). Resting-state functional magnetic resonance imaging (fMRI) scans were collected with SIEMENS 3T scanner while subjects were in a fasting state. Results Participants with SJL had significantly higher fALFF values in right lingual gyrus and right putamen and significantly lower fALFF values in left and right inferior parietal lobe in comparison with participants without SJL and without sleep deprivation. Subjects with sleep deprivation had significantly higher fALFF in the thalamus and left superior frontal gyrus. In those with both SJL and sleep deprivation, we observed higher fALFF values in right Brodmann Area (BA)18 and lower values in left and right parietal inferior lobe. Subjects with SJL alone had significantly lower fALFF values in left frontal mid gyrus (BA6) than those with sleep deprivation alone. Conclusions SJL was associated with altered resting-state brain activity in regions that have been shown to be involved in hedonic feeding. The effect of SJL was independent of effects induced by short sleep duration. These alterations might represent the substrate for the increased risk of obesity observed in those with SJL. |
Databáze: | OpenAIRE |
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