Safety considerations and dosing guidelines for encainide in supraventricular arrhythmias
| Autor: | Lester F. Soyka |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Nausea Encainide Cardiomyopathy Drug Administration Schedule Internal medicine Tachycardia Supraventricular Humans Medicine Anilides cardiovascular diseases Dosing Adverse effect Proarrhythmia Supraventricular arrhythmia business.industry Hemodynamics Arrhythmias Cardiac Middle Aged medicine.disease Anesthesia Heart failure Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | The American Journal of Cardiology. 62:L63-L68 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(88)90019-7 |
| Popis: | The safety issues relevant to treatment with encainide in patients with supraventricular arrhythmia were reviewed based on 349 patients enrolled in clinical trials in the United States and Europe. Although 20% of patients had a history of congestive heart failure, cardiomegaly, or cardiomyopathy at entry, there was no case of new or worsened heart failure. There were 5 cases (1.4%) of proarrhythmia in adults, reflecting a worsening of the arrhythmia being treated or of a coexisting ventricular arrhythmia. The profile of drug-related adverse effects was comparable to that previously reported, causing discontinuance in 6% of patients. The effects most often seen were dizziness, visual disturbance, headache, nausea and vertigo. Only 1 patient had clinically significant abnormal laboratory values, possibly reflecting hepatocellular injury in conjunction with viral hepatitis. Most responders received a daily dose of 75 to 200 mg/day, generally given in 3 divided doses. Encainide has a very favorable safety profile for use in the treatment of supraventricular arrhythmias. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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