Vinpocetine Effect on the Juncture of Diabetes and Aging: An in-vitro study
| Autor: | Mohammad Abdollahi, Maryam Baeeri, Mahban Rahimifard, Hamed Haghi-Aminjan, Shermineh Moini-Nodeh, Mahshid Hodjat |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Metabolite Population Vincamine Inflammation Pharmacology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Vinpocetine Diabetes mellitus Drug Discovery Diabetes Mellitus medicine Animals Humans education Vinca Alkaloids Aged education.field_of_study geography geography.geographical_feature_category business.industry NF-kappa B General Medicine medicine.disease Islet Rats Oxidative Stress 030104 developmental biology chemistry medicine.symptom business 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Drug Research. 71:438-447 |
| ISSN: | 2194-9387 2194-9379 |
| Popis: | The rapid-growing population of diabetic patients and the elderly are among the direst challenges that the science of medicine is facing today. Targeting these two challenges can shed light on new means to control and ideally reverse this trend. In this experiment, Vinpocetine's effect on aged pancreatic beta-cell functions in correlation with oxidative stress was studied.Islet cells were isolated from the pancreas of aged rats and exposed to Vinpocetine, dissolved in acetone and RPMI, for 48 h. Then, senescence-associated molecular parameters, includingExperimental results showed that Vinpocetine could significantly increase aged islets insulin secretion and also make a meaningful reduction in oxidative stress markers. This drug can also decrease expression levels ofThe current study showed that Vinpocetine, a derivative of the secondary plant metabolite called Vincamine, could break this vicious cycle of oxidative stress and aging by reducing oxidative stress and inflammation, thus inhibiting cellular aging.The rapid-growing population of diabetic patients and the elderly are among the direst challenges that the science of medicine is facing today. Targeting these two challenges can shed light on new means to control and ideally reverse this trend. In this experiment, Vinpocetine’s effect on aged pancreatic beta-cell functions in correlation with oxidative stress was studied.Islet cells were isolated from the pancreas of aged rats and exposed to Vinpocetine, dissolved in acetone and RPMI, for 48 h. Then, senescence-associated molecular parameters, includingExperimental results showed that Vinpocetine could significantly increase aged islets insulin secretion and also make a meaningful reduction in oxidative stress markers. This drug can also decrease expression levels ofThe current study showed that Vinpocetine, a derivative of the secondary plant metabolite called Vincamine, could break this vicious cycle of oxidative stress and aging by reducing oxidative stress and inflammation, thus inhibiting cellular aging. |
| Databáze: | OpenAIRE |
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