Safety of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells for Treating Interstitial Cystitis: A Phase I Study

Autor:	Jung Hyun Shin, Chae-Min Ryu, Hwan Yeul Yu, Juhyun Park, Ah Reum Kang, Jeong Min Shin, Ki-Sung Hong, Eun Young Kim, Hyung-Min Chung, Dong-Myung Shin, Myung-Soo Choo
Rok vydání:	2022
Předmět:	Human Embryonic Stem Cells Urinary Bladder Cystitis Interstitial Humans Pain Female Mesenchymal Stem Cells Cell Biology General Medicine Developmental Biology
Zdroj:	Stem Cells Translational Medicine. 11:1010-1020
ISSN:	2157-6580 2157-6564
Popis:	There are still no definite treatment modalities for interstitial cystitis (IC). Meanwhile, stem cell therapy is rising as potential alternative for various chronic diseases. This study aimed to investigate the safety of the clinical-grade mesenchymal stem cells (MSCs) derived from human embryonic stem cells (hESCs), code name MR-MC-01 (SNU42-MMSCs), in IC patients. Three female IC patients with (1) symptom duration >6 months, (2) visual pain analog scale (VAS) ≥4, and (3) one or two Hunner lesions
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5373732d34bf67dd1503b56b5eebbf https://doi.org/10.1093/stcltm/szac065 Zobrazit plný text záznamu