DEPRESSION AND ANXIETY OCCURRING DURING RAUWOLFIA THERAPY
| Autor: | W. W. Pryor, James E. Gibbons, Edward S. Orgain, John C. Muller |
|---|---|
| Rok vydání: | 1955 |
| Předmět: |
Drug
medicine.medical_specialty media_common.quotation_subject Anxiety Rauwolfia Internal medicine Humans Medicine Antihypertensive Agents Depression (differential diagnoses) media_common Depressive Disorder Depression business.industry Alkaloid Reserpine Anxiety Disorders Secologanin Tryptamine Alkaloids Surgery Diarrhea medicine.symptom Complication business Weight gain medicine.drug |
| Zdroj: | Journal of the American Medical Association. 159:836 |
| ISSN: | 0002-9955 |
| DOI: | 10.1001/jama.1955.02960260006002 |
| Popis: | During recent years extracts of Rauwolfia serpentina have been utilized freely in the treatment of hypertensive vascular disease and varied psychiatric illnesses. Initial preparations for clinical investigation were provided only in crude form; but a highly purified alkaloid, reserpine, is now available. In general, the pharmacological properties of the crude and the purified derivatives are essentially the same.1These compounds are considered to be free of serious toxic reactions.2Mild side-effects frequently encountered are nasal stuffiness, decreased initiative, fatigue, weight gain, drowsiness, nightmares, and diarrhea. These symptoms usually can be relieved by reducing the dosage of the drug without appreciably sacrificing its hypotensive effect.3In some patients receiving Rauwolfia preparations in large doses, depression may develop.4Although this complication occurs with significant frequency, it has received comparatively little emphasis in the literature. The purpose of this paper is to report the cases of 7 patients (of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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