Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF‐16/FOXO
| Autor: | Sangsoon Park, Yunji Choi, Seung-Jae Lee, Murat Artan, Kyuhyung Kim, Dae-Eun Jeong, Hae-Eun H. Park, Yoonji Jung, Heehwa G. Son, Sieun S. Kim, Jin I. Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
media_common.quotation_subject medicine.medical_treatment Longevity Down-Regulation Diacetyl 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Downregulation and upregulation medicine Animals Receptor Caenorhabditis elegans Caenorhabditis elegans Proteins Transcription factor media_common biology Insulin aging C. elegans Short Take dietary restriction Forkhead Transcription Factors Cell Biology biology.organism_classification Cell biology 030104 developmental biology Odor chemistry Odorants 030217 neurology & neurosurgery Diet Therapy |
| Zdroj: | Aging Cell |
| ISSN: | 1474-9726 1474-9718 |
| Popis: | Dietary restriction extends lifespan in various organisms by reducing the levels of both nutrients and non‐nutritional food‐derived cues. However, the identity of specific food‐derived chemical cues that alter lifespan remains unclear. Here, we identified several volatile attractants that decreased the longevity on food deprivation, a dietary restriction regimen in Caenorhabditis elegans. In particular, we found that the odor of diacetyl decreased the activity of DAF‐16/FOXO, a life‐extending transcription factor acting downstream of insulin/IGF‐1 signaling. We then demonstrated that the odor of lactic acid bacteria, which produce diacetyl, reduced the nuclear accumulation of DAF‐16/FOXO. Unexpectedly, we showed that the odor of diacetyl decreased longevity independently of two established diacetyl receptors, ODR‐10 and SRI‐14, in sensory neurons. Thus, diacetyl, a food‐derived odorant, may shorten food deprivation‐induced longevity via decreasing the activity of DAF‐16/FOXO through binding to unidentified receptors. Food deprivation, a dietary restriction regimen in C. elegans, promotes longevity by increasing nuclear localization and transcriptional activity of DAF‐16/FOXO. The odor of diacetyl, a volatile organic compound that is produced by lactic acid bacteria, decreases food deprivation‐mediated longevity by downregulating DAF‐16/FOXO via an unidentified receptor. Our data indicate that specific food odors can reduce longevity in animals. |
| Databáze: | OpenAIRE |
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