Multi-domain potential biomarkers for post-traumatic stress disorder (PTSD) severity in recent trauma survivors
| Autor: | Nimrod Jackob Keynan, Ziv Ben-Zion, Pinchas Halpern, Talma Hendler, Haggai Sharon, Yoav Zeevi, Arieh Y. Shalev, Roee Admon, Tal Kozlovski, Israel Liberzon, Yoav Benjamini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Psychometrics Article lcsh:RC321-571 Stress Disorders Post-Traumatic Young Adult Cellular and Molecular Neuroscience Humans Medicine Survivors lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Depression (differential diagnoses) Post-traumatic stress disorder (PTSD) business.industry Cognitive flexibility Cognition Middle Aged medicine.disease Anxiety Disorders Magnetic Resonance Imaging Cognitive test Psychiatry and Mental health Anxiety Female medicine.symptom Psychiatric disorders business Insula Biomarkers Neuroscience Clinical psychology |
| Zdroj: | Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020) Translational Psychiatry |
| ISSN: | 2158-3188 |
| Popis: | Contemporary symptom-based diagnosis of post-traumatic stress disorder (PTSD) largely overlooks related neurobehavioral mechanisms and relies entirely on subjective interpersonal reporting. Previous studies associating biomarkers with PTSD have mostly used symptom-based diagnosis as the main outcome measure, disregarding the wide variability and richness of PTSD phenotypical features. Here, we aimed to computationally derive potential biomarkers that could efficiently differentiate PTSD subtypes among recent trauma survivors. A three-staged semi-unsupervised method (“3C”) was used to firstly categorize individuals by current PTSD symptom severity, then derive clusters based on clinical features related to PTSD (e.g. anxiety and depression), and finally to classify participants’ cluster membership using objective multi-domain features. A total of 256 features were extracted from psychometrics, cognitive functioning, and both structural and functional MRI data, obtained from 101 adult civilians (age = 34.80 ± 11.95; 51 females) evaluated within 1 month of trauma exposure. The features that best differentiated cluster membership were assessed by importance analysis, classification tree, and ANOVA. Results revealed that entorhinal and rostral anterior cingulate cortices volumes (structural MRI domain), in-task amygdala’s functional connectivity with the insula and thalamus (functional MRI domain), executive function and cognitive flexibility (cognitive testing domain) best differentiated between two clusters associated with PTSD severity. Cross-validation established the results’ robustness and consistency within this sample. The neural and cognitive potential biomarkers revealed by the 3C analytics offer objective classifiers of post-traumatic morbidity shortly following trauma. They also map onto previously documented neurobehavioral mechanisms associated with PTSD and demonstrate the usefulness of standardized and objective measurements as differentiating clinical sub-classes shortly after trauma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|