Red cell volume measurement – using indium as a replacement for chromium
| Autor: | Stéphanie Becker, David Tonnelet, Juliette Dinet, Pierre Bohn, Joseph Le Cloirec |
|---|---|
| Přispěvatelé: | Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU) |
| Rok vydání: | 2020 |
| Předmět: |
Chromium
[SDV]Life Sciences [q-bio] chemistry.chemical_element 030204 cardiovascular system & hematology MESH: Chromium Radioisotopes Red cell volume Technetium Chromium Radioisotopes Indium Cell size 03 medical and health sciences MESH: Chromium 0302 clinical medicine Erythrocyte volume Medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Letters to the Editor ComputingMilieux_MISCELLANEOUS MESH: Cell Size Cell Size Erythrocyte Volume business.industry Chemistry Radiochemistry Indium Radioisotopes General Medicine MESH: Indium Red cell volume measurement Isotope Labeling MESH: Technetium business Biomedical engineering |
| Zdroj: | Nuclear Medicine Communications Nuclear Medicine Communications, Lippincott, Williams & Wilkins, 2020, 41 (10), pp.1106-1107. ⟨10.1097/MNM.0000000000001258⟩ |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/mnm.0000000000001185 |
| Popis: | The withdrawal of Cr-chromate has meant that the technique commonly used for direct measurement of red cell volume has had to be replaced. Most centres moved to a Tc erythrocyte label, however, Tc is known to dissociate over time. We have investigated an alternative technique using an In-chloride and tropolone solution and tested this both in vitro and in vivo. Initial in-vitro and in-vivo work, which included a check of the stability of the radio-labelled product at one hour, demonstrated this label to be stable over this time period. To date, 20 patients have undergone this technique and results show that this technique is a viable alternative to Cr-chromate particularly for patients with splenomegaly who require late sampling. This procedure is now in routine use in our institution. |
| Databáze: | OpenAIRE |
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