Towards improved HIV-microbicide activity through the co-encapsulation of NRTI drugs in biocompatible metal organic framework nanocarriers
| Autor: | M. T. Marcos-Almaraz, Christine Kreuz, Valentina Agostoni, Patricia Horcajada, Ruxandra Gref, Pascal Clayette, Patrick Couvreur, Christian Serre |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Materials science media_common.quotation_subject Biomedical Engineering virus diseases 02 engineering and technology General Chemistry General Medicine Pharmacology Prodrug 010402 general chemistry 021001 nanoscience & nanotechnology Biocompatible material 01 natural sciences In vitro 0104 chemical sciences Nucleoside Reverse Transcriptase Inhibitor Microbicide General Materials Science Metal-organic framework Nanocarriers 0210 nano-technology media_common |
| Zdroj: | Journal of Materials Chemistry B. 5:8563-8569 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/c7tb01933e |
| Popis: | The efficacy of the routinely used anti-HIV (Human Immunodeficiency Virus) therapy based on nucleoside reverse transcriptase inhibitors (NRTIs) is limited by the poor cellular uptake of the active triphosphorylated metabolites and the low efficiency of intracellular phosphorylation of their prodrugs. Nanoparticles of iron(iii) polycarboxylate Metal-Organic Frameworks (nanoMOFs) are promising drug nanocarriers. In this study, two active triphosphorylated NRTIs, azidothymidine triphosphate (AZT-Tp) and lamivudine triphosphate (3TC-Tp), were successfully co-encapsulated into the biocompatible mesoporous iron(iii) trimesate MIL-100(Fe) nanoMOF in order to improve anti-HIV therapies. The drug loaded nanoMOFs could be stored for up to 2-months and reconstituted after freeze drying, retaining similar physicochemical properties. Their antiretroviral activity was evidenced in vitro on monocyte-derived macrophages experimentally infected with HIV, making these co-encapsulated nanosystems excellent HIV-microbicide candidates. |
| Databáze: | OpenAIRE |
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