Epileptic seizures but not pseudoseizures are associated with decreased density of the serotonin transporter in blood platelet membranes
| Autor: | Daniela Audenino, Aroldo Cupello, Elena Gatta, Michele Fornaro, Pantaleo Fornaro, S. Scarrone, Claudio Albano |
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| Přispěvatelé: | Cupello, Aroldo, Audenino, Daniela, Scarrone, Simona, Fornaro, Michele, Gatta, Elena, Fornaro, Pantaleo, Albano, Claudio |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Blood Platelets
Adult Male medicine.medical_specialty Adolescent Tritium Biochemistry Cellular and Molecular Neuroscience Epilepsy blood Internal medicine medicine Anticonvulsant Psychogenic disease Humans Platelet Neurochemistry Serotonin transporter Aged Serotonin Plasma Membrane Transport Proteins biology Adolescent Adult Aged Anticonvulsants therapeutic use Blood Platelets metabolism Cell Membrane metabolism Epilepsy blood/drug therapy Female Humans Male Middle Aged Paroxetine metabolism Serotonin Plasma Membrane Transport Proteins blood Tritium business.industry Cell Membrane General Medicine Middle Aged medicine.disease Paroxetine Endocrinology Anesthesia therapeutic use biology.protein Blood Platelet Anticonvulsants Female Serotonin business metabolism blood/drug therapy Homeostasis Serotonin Plasma Membrane Transport Protein medicine.drug Human |
| Popis: | The density of the serotonin transporter in the plasma membranes of blood platelets was evaluated by labelled paroxetine binding in three different groups. These groups were: normal controls, epileptic patients having undergone a recent seizure (less than 4 days before) and patients who equally recently presented psychogenic non-epileptic seizures (pseudoseizures). Real seizures resulted in a significant decrease of membrane serotonin transporter density. In the instances of pseudoseizures, its membrane density was undistinguishable from that of normal controls. These data lend further support to the idea that down regulation of serotonin transporter may play a homeostatic role in the cessation of epileptic seizures. |
| Databáze: | OpenAIRE |
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