Divergent Effects of Aging and Sex on Vasoconstriction to Endothelin in Coronary Arterioles

Autor:	Bei Chen, Rafael A. Reyes, Patrick J. Dougherty, Donna H. Korzick, Robert D. Shipley, Amanda J. LeBlanc, Judy M. Muller-Delp
Rok vydání:	2013
Předmět:	Male medicine.hormone Aging medicine.medical_specialty Heart disease Physiology Vasodilation Article Endothelins Coronary circulation Coronary Circulation Physiology (medical) Internal medicine medicine Animals Receptor Molecular Biology Sex Characteristics Receptors Endothelin business.industry medicine.disease Coronary Vessels Rats Inbred F344 Rats Arterioles medicine.anatomical_structure Endocrinology Vasoconstriction cardiovascular system Vascular resistance Female Vascular Resistance medicine.symptom Cardiology and Cardiovascular Medicine Endothelin receptor business circulatory and respiratory physiology
Zdroj:	Microcirculation. 20:365-376
ISSN:	1073-9688
Popis:	The risk for cardiovascular disease increases with advancing age; however, the chronological development of heart disease differs in males and females. The purpose of this study was to determine whether age-induced alterations in responses of coronary arterioles to the endogenous vasoconstrictor, endothelin, are sex-specific. Coronary arterioles were isolated from young and old male and female rats to assess vasoconstrictor responses to endothelin (ET), and ETa and ETb receptor inhibitors were used to assess receptor-specific signaling. In intact arterioles from males, ET-induced vasoconstriction was reduced with age, whereas age increased vasoconstrictor responses to ET in intact arterioles from female rats. In intact arterioles from both sexes, blockade of either ETa or ETb eliminated age-related differences in responses to ET; however, denudation of arterioles from both sexes revealed age-related differences in ETa-mediated vasoconstriction. In arterioles from male rats, ETa receptor protein decreased, whereas ETb receptor protein increased with age. In coronary arterioles from females, neither ETa nor ETb receptor protein changed with age, suggesting age-related changes in ET signaling occur downstream of ET receptors. Thus, aging-induced alterations in responsiveness of the coronary resistance vasculature to endothelin are sex-specific, possibly contributing to sexual dimorphism in the risk of cardiovascular disease with advancing age.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4c6c2f5c3f5aad4e7a5d110bcd10c1 https://doi.org/10.1111/micc.12028 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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