Early response and safety of atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma in patients who do not meet IMbrave150 eligibility criteria

Autor:	Takuya Sho, Ken Furuya, Masaru Baba, Masatsugu Ohara, Kazuharu Suzuki, Osamu Maehara, Taku Shigesawa, Jun Ito, Shunsuke Ohnishi, Yoshimasa Tokuchi, Katsumi Terashita, Koji Ogawa, Naoki Kawagishi, Takaaki Izumi, Takashi Kitagataya, Megumi Kimura, Akinori Kubo, Masato Nakai, Takashi Meguro, Kenichi Morikawa, Akihisa Nakamura, Takuto Miyagishima, Mitsuteru Natsuizaka, Naoya Sakamoto, Goki Suda, Yoshiya Yamamoto, Ren Yamada
Rok vydání:	2021
Předmět:	medicine.medical_specialty Hepatology Bevacizumab Combination therapy business.industry medicine.disease Clinical trial Infectious Diseases Atezolizumab Response Evaluation Criteria in Solid Tumors Internal medicine Hepatocellular carcinoma medicine business Adverse effect Progressive disease medicine.drug
Zdroj:	Hepatology research : the official journal of the Japan Society of HepatologyREFERENCES. 51(9)
ISSN:	1386-6346
Popis:	AIM A clinical trial (IMbrave150) indicated the efficacy and safety of atezolizumab plus bevacizumab for patients with unresectable hepatocellular carcinoma (HCC). In this study, we evaluated this therapeutic combination in a real-world setting, with a focus on patients who did not meet the IMbrave150 eligibility criteria. METHODS In this multicenter study, patients with unresectable HCC treated with atezolizumab plus bevacizumab between October 2020 and May 2021 were screened. In patients who did not meet IMbrave150 eligibility criteria, treatment responses and safety at 6 and 12 weeks were evaluated. RESULTS Atezolizumab plus bevacizumab was initiated in 64 patients, including 46 patients (71.9%) who did not meet IMbrave150 eligibility criteria. Most of these patients had a history of systemic therapy (44/46). The objective response rate and disease control rate observed using Response Evaluation Criteria in Solid Tumors 1.1 were 5.2% and 82.8% at 6 weeks and 10.0% and 84.0% at 12 weeks, respectively; these rates were similar between patients who met and did not meet the IMbrave150 criteria. Ten patients experienced progressive disease (PD) at 6 weeks. Portal vein tumor thrombosis was significantly associated with PD (p = 0.039); none of the 15 patients with hepatitis B virus-related HCC experienced PD (p = 0.050). The most common adverse events of grade 3 or higher were aspartate aminotransferase elevation (n = 8, 13.8%) and the safety profile was similar between patients who met and did not meet the IMbrave150 criteria. CONCLUSION Most patients treated with atezolizumab plus bevacizumab did not meet the IMbrave150 criteria; however, the combination therapy showed good safety and efficacy at the early treatment phase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4bd6f1334755d87e2145f4d036344d https://pubmed.ncbi.nlm.nih.gov/34245216 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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