The evaluation of doxorubicin-induced cardiotoxicity: Comparison of Doppler and tissue Doppler-derived myocardial performance index
| Autor: | Osman Sonmez, Kenan Demir, M. Akif Vatankulu, Selim Ayhan, Mehmet Kayrak, Ahmet Bacaksiz, Fatih Koç, Hasan Gök, Önder Eren, Hatem Ari, Cetin Duman, Kurtulus Ozdemir, Hakan Gulec |
|---|---|
| Přispěvatelé: | BAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ayhan, S. Selim, Selçuk Üniversitesi |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Heart Diseases Turkey cardiotoxicity Early detection doxorubicin Doppler imaging Ventricular Function Left symbols.namesake Predictive Value of Tests Internal medicine medicine Humans Doxorubicin myocardial performance index Myocardial Performance Index Echocardiography Doppler Pulsed Cardiotoxicity Antibiotics Antineoplastic business.industry General Medicine Middle Aged Myocardial Contraction Echocardiography Doppler Early Diagnosis Predictive value of tests Rv function Ventricular Function Right symbols Cardiology Female Cardiology and Cardiovascular Medicine business Doppler effect medicine.drug |
| Zdroj: | Cardiology Journal. 19:363-368 |
| ISSN: | 1897-5593 |
| DOI: | 10.5603/cj.2012.0066 |
| Popis: | WOS: 000309036000005 PubMed: 22825896 Background: Doxorubicin is a chemotherapeutic agent used in a wide spectrum of cancers. However, cardiotoxic effects have limited its clinical use. The early detection of doxorubicin-induced cardiotoxicity is crucial. The purpose of our study was to assess values of Doppler and tissue Doppler imaging (TDI) -derived myocardial performance index (MPI) in adult cancer patients receiving doxorubicin treatment. Methods: A total of 45 patients underwent echocardiographic examinations before any doxorubicin had been administered and then after doxorubicin. Doppler and TDI-derived MPI of left ventricular (LV) were determined in the evaluation of cardiotoxicity. Additionally, TDI-derived MPI of right ventricular (RV) was determined. Results: All patients underwent control echocardiographic examination after mean 5 +/- 1.7 months. The LV MPI obtained by both Doppler and TDI were increased after doxorubicin treatment (0.56 +/- 0.11, 0.61 +/- 0.10, p = 0,005 vs 0.51 +/- 0.09, 0.59 +/- 0.09, p = 0.001, respectively). There was no correlation between Doppler-derived MPI and cumulative doxorubicin dose (coefficient of correlation 0.11, p = 0.6). TDI-derived MPI was correlated with cumulative doxorubicin dose (coefficient of correlation 0.35, p = 0.015), but this correlation is weak (r = 0.38). The study population was divided into two groups according to doxorubicin dose (below and above 300 mg level). There was a moderate correlation between TDI-derived MPI and less than 300 mg of doxorubicin dose (coefficient of correlation 0.51, p = 0.028). However, Doppler-derived MPI was not correlated with less than 300 mg of doxorubicin dose (coefficient of correlation 0.38, p = 0.123). Also, there was no significant change in the TDI-derived RV-MPI (0.49 +/- 0.14, 0.50 +/- 0.12, p = 0.56). Conclusions: TDI-derived MPI is a useful parameter and an early indicator compared with Doppler-derived MPI in the detection of cardiotoxicity during the early stages. Also, doxorubicin administration does not affect RV function. (Cardiol J 2012; 19,4: 363-368) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|