Different MOG35–55 concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-β in mice CNS despite unchanged clinical course
| Autor: | Sandra B.R. Castro, Marcilene Gomes Evangelista, Maria A. Juliano, Caio César de Souza Alves, Felipe Pereira Mesquita, Maria Christina Marques Nogueira Castañon, Nathália Stela Visoná de Figueiredo, Alyria Teixeira Dias, Ana Paula Ferreira |
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| Rok vydání: | 2015 |
| Předmět: |
Chemokine
Encephalomyelitis Autoimmune Experimental medicine.medical_treatment Immunology Inflammation Autoimmunity medicine.disease_cause Statistics Nonparametric Pathogenesis Multiple sclerosis Mice immune system diseases medicine Animals Animal model biology business.industry Experimental autoimmune encephalomyelitis Brain MOG35–55 Flow Cytometry medicine.disease nervous system diseases Mice Inbred C57BL Disease Models Animal Interleukin 10 Cytokine Spinal Cord biology.protein Cytokines Female Myelin-Oligodendrocyte Glycoprotein Chemokines medicine.symptom business |
| Zdroj: | Cellular Immunology. 293(2):87-94 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2014.12.009 |
| Popis: | Multiple sclerosis (MS) shows distinct clinical courses. Experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis, can be induced by different protocols, which show distinct cytokine and antibody production. The factors involved in this heterogeneity remain unclear. The relevance of MOG concentration in triggering a regulatory response in the chronic model of EAE is imprecise. The aim of this study was investigate if 100 or 300 μg of MOG 35 – 55 could induce different EAE profiles. Modifications in the concentration of MOG were able to change the patterns of chemokines, cytokines, percentage of cells, inflammatory infiltrate and the development of a regulatory response. However, these changes were unable to modify the intensity of response, which explains the chronic progression of the disease in both concentrations. The results presented in this study contribute to understanding the intricate mechanisms that trigger EAE and provide insights into the pathogenesis of various forms of MS. |
| Databáze: | OpenAIRE |
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