Acquired dysfibrinogenemia. Paraneoplastic syndrome in renal cell carcinoma
| Autor: | Barbara M. Alving, Nancy A. Dawson, Charles F. Barr |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Paraneoplastic Syndromes Thrombin Time Urology medicine.medical_treatment Thrombin time Fibrinogen Malignancy Nephrectomy chemistry.chemical_compound Thrombin Renal cell carcinoma Carcinoma medicine Humans Dysfibrinogenemia Carcinoma Renal Cell Fibrin medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Kidney Neoplasms N-Acetylneuraminic Acid Sialic acid chemistry Tumor progression Sialic Acids Female business Follow-Up Studies medicine.drug |
| Zdroj: | The American Journal of Medicine. 78:682-686 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(85)90414-0 |
| Popis: | Acquired dysfibrinogenemia has not been previously reported as a paraneoplastic marker for malignancy. This report describes the clinical course of a patient who at the time of diagnosis of nonmetastatic renal cell carcinoma had dysfibrinogenemia characterized by prolongation of the thrombin and Reptilase times and increased sialic acid content of the purified fibrinogen. The thrombin and Reptilase times returned toward normal values after nephrectomy but became abnormal with the development of nonhepatic metastases. It is concluded that acquired dysfibrinogenemia can be part of a paraneoplastic syndrome and is a sensitive plasma marker for tumor progression. |
| Databáze: | OpenAIRE |
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