Monoamine turnover in the brain of mice during development of tolerance to the anticonvulsant effect of clonazepam
| Autor: | R. Scherkl, Hans-Hasso Frey, S Jung |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Ratón medicine.medical_treatment Clonazepam Midbrain Norepinephrine Epilepsy Mice Dopamine Internal medicine medicine Animals Biogenic Monoamines Brain Chemistry business.industry Drug Tolerance medicine.disease Endocrinology Anticonvulsant Neurology Neurology (clinical) Serotonin business medicine.drug |
| Zdroj: | Epilepsy research. 8(3) |
| ISSN: | 0920-1211 |
| Popis: | Mice were treated for 14 days with clonazepam, 0.5 mg/kg i.p. twice daily, during which time partial tolerance to the anticonvulsant effect against pentetrazole developed. The development of tolerance was paralleled by a reduced turnover of noradrenaline in the whole brain, and of dopamine in the midbrain. The turnover of 5-HT was increased during the first week of treatment, but decreased thereafter. These changes in monoamine turnover, which are thought to be GABA-mediated, are consistent with an increased seizure susceptibility, and may contribute to the development of tolerance to the anticonvulsant effect of benzodiazepines. |
| Databáze: | OpenAIRE |
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