Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity
| Autor: | Yoav Bauman, Orly Ben-nun-Shaul, Ofer Mandelboim, Yael Ophir, Ariella Oppenheim, Alon Vitenstein, Rachel Yamin, Nir Drayman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cytotoxicity
Immunologic 0301 basic medicine viruses Population Down-Regulation chemical and pharmacologic phenomena NK cells Simian virus 40 Biology GPI-Linked Proteins Virus NKG2D Cell Line SV40 03 medical and health sciences 0302 clinical medicine Immune system Downregulation and upregulation Animals Humans immune-evasion Immune response Receptor education Immune Evasion Polyomavirus Infections education.field_of_study Research Paper: Immunology Immunity Intracellular Signaling Peptides and Proteins biochemical phenomena metabolism and nutrition Virology 3. Good health Killer Cells Natural Tumor Virus Infections ULBP1 030104 developmental biology Oncology 030220 oncology & carcinogenesis Immunology and Microbiology Section |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.8085 |
| Popis: | Polyomaviruses are a diverse family of viruses which are prevalent in the human population. However, the interactions of these viruses with the immune system are not well characterized. We have previously shown that two human polyomaviruses, JC and BK, use an identical microRNA to evade immune attack by Natural Killer (NK) cells. We showed that this viral microRNA suppresses ULBP3 expression, a stress induced ligand for the killer receptor NKG2D. Here we show that Simian Virus 40 (SV40) also evades NK cell attack through the down regulation of another stress-induced ligand of NKG2D, ULBP1. These findings indicate that NK cells play an essential role in fighting polyomavirus infections and further emphasize the importance of various members of the ULBP family in controlling polyomavirus infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|