Evaluation of structural, spectral characterization and in vitro cytotoxic activity studies of some polycyclic aromatic compounds
| Autor: | Aysegul Kose, Koray Sayin, Muhammet Kose, Majid Rezaeivala, Derya Tandoğan, Serap Şahin-Bölükbaşı |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cytotoxic activity
Chemistry General Chemical Engineering Theoretical Studies 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Electrochemistry 01 natural sciences Combinatorial chemistry Fluorescence In vitro 0104 chemical sciences lcsh:Chemistry lcsh:QD1-999 Cell culture Excited state Cancer cell Cytotoxic T cell Polycyclic aromatic compound 0210 nano-technology Selectivity Photoluminescence |
| Zdroj: | Arabian Journal of Chemistry, Vol 13, Iss 6, Pp 5593-5604 (2020) |
| ISSN: | 1878-5352 |
| Popis: | The present study aims to introduce three known and three new stable polycyclic aromatic compounds synthesized. With MALDI-Mass, 1H and 13C NMR spectroscopy, all new compounds were characterized. In the DMF solution were carried out the electrochemical and photophysical properties of the polyaromatic compounds. The compounds are highly fluorescent showing green-red emission when excited at one single wavelength. For the compound 3, it was shown that the highest Stokes Shift (191 nm) appeared which may be due to the excited state energy transfer. The compounds also indicated the blue-orange region of the electromagnetic spectrum strong emission bands. Additionally, compounds 1, 3, 4, and 5 were investigated for their in vitro cytotoxic activities against PC-3 prostate cancer cells, L-929 non-cancerous cells, and MDA-MB-231 breast cancer for 24 h, 48 h and 72 h. The results obtained from the experiment demonstrated that compounds had different cytotoxic activity against cell lines. Compound 3 was indicated to be inactive against L-929 cells and MDA-MB-231 cancer cells, whereas compounds 1, 4 and 5 indicated a dose and time-dependent cytotoxic activity against PC-3, MDA-MB-231, and L-929 cell lines. It was found that the most sensitive cells to compound 5 were MDA-MB-231 human breast cancer cells. Additionally, it became clear that compounds 1 and 3 had significant selectivity for human PC-3 prostate cancer cells, and compounds 1, 4 and 5 had considerable selectivity for human MDA-MB-231 breast cancer cells. Also, the quantum chemical examinations of six organic compounds were conducted at the B3LYP/6-31G level in the gas phase and water. According to calculated results, compound 5 was found to be the best candidate for NLO applications. |
| Databáze: | OpenAIRE |
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