Critique of the paper: could pesticide toxicology studies be more relevant to occupational risk assessment? (by Ross et al., 2001)
| Autor: | Neil G. Carmichael |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Engineering
business.industry Occupational risk Public Health Environmental and Occupational Health Reproducibility of Results Guidelines as Topic General Medicine Guideline Percutaneous penetration Administration Cutaneous Risk Assessment Rats Toxicology studies Disease Models Animal Risk analysis (engineering) Research Design Occupational Exposure Toxicity Tests Forensic engineering Animals Humans Pesticides business Risk assessment Pesticide Toxicology |
| Zdroj: | The Annals of occupational hygiene. 45 |
| ISSN: | 0003-4878 |
| Popis: | The toxicology studies required for the registration of a pesticide are not necessarily well adapted to user safety assessment. This problem can be overcome in some cases by improving the guideline studies. In other cases the guidelines are based on animal models which are poor models for man; the most obvious example is rat percutaneous penetration. In other cases it may simply be impractical to have a model which can be extrapolated to all exposure situations. This is the case for intermittent exposure which is infinitely variable. The general conclusion is that the entire data package should be re-examined to make it more relevant to risk assessment. |
| Databáze: | OpenAIRE |
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