Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease during Treatment Reveals Changing Coinfection with Mixtures of Borrelia burgdorferi Genotypes

Autor:	Mark J. Soloski, John N. Aucott, Steven Castro, Christian Massire, Michael R. Mosel, Heather E. Carolan, David J. Ecker, Mark W. Eshoo, Alison W. Rebman
Rok vydání:	2019
Předmět:	Spectrometry Mass Electrospray Ionization Genotype medicine.drug_class Electrospray ionization Antibiotics Clinical Therapeutics Polymerase Chain Reaction law.invention 03 medical and health sciences Lyme disease law Antibiotic therapy Humans Medicine Pharmacology (medical) Borrelia burgdorferi Polymerase chain reaction 030304 developmental biology Pharmacology Lyme Disease 0303 health sciences biology 030306 microbiology business.industry bacterial infections and mycoses biology.organism_classification medicine.disease Virology Anti-Bacterial Agents Infectious Diseases Coinfection business
Zdroj:	Antimicrobial Agents and Chemotherapy. 63
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.00237-19
Popis:	Borrelia burgdorferi is the etiological agent of Lyme disease. In the current study, we used direct-detection PCR and electrospray ionization mass spectrometry to monitor and genotype B. burgdorferi isolates from serially collected whole-blood specimens from patients clinically diagnosed with early Lyme disease before and during 21 days of antibiotic therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a40c591e5692659c13680148a11b35d https://doi.org/10.1128/aac.00237-19 Zobrazit plný text záznamu