Review: Rho kinase as a therapeutic target in the treatment of asthma and chronic obstructive pulmonary disease
| Autor: | Peter J. Henry, Lynette B. Fernandes, Roy G. Goldie |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pyridines Pulmonary Disease Chronic Obstructive 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Humans Pharmacology (medical) Enzyme Inhibitors Pulmonary Eosinophilia Rho-associated protein kinase Asthma lcsh:RC705-779 rho-Associated Kinases COPD business.industry lcsh:Diseases of the respiratory system respiratory system medicine.disease Amides respiratory tract diseases Y-27632 Bronchodilatation 030228 respiratory system chemistry Rho kinase inhibitor 030220 oncology & carcinogenesis Immunology Bronchoconstriction medicine.symptom business |
| Zdroj: | Therapeutic Advances in Respiratory Disease, Vol 1 (2007) |
| ISSN: | 1753-4666 |
| Popis: | Asthma is a complex inflammatory disease of the airways involving reversible bronchoconstriction. Chronic obstructive pulmonary disease is typified by inflammation and airflow limitation that has an irreversible component. There is now substantial evidence that Rho kinase is involved in many of the pathways that contribute to the pathologies associated with these respiratory diseases including bronchoconstriction, airway inflammation, airway remodelling, neuromodulation and exacerbations due to respiratory tract viral infection. Indeed the Rho kinase inhibitor Y-27632 causes bronchodilatation and reduces pulmonary eosinophilia trafficking and airways hyperresponsiveness. Furthermore, accumulating evidence suggests that inhibition of Rho kinase could have a major beneficial impact on symptoms and disease progression in asthma and COPD by modulating several other systems and processes. Thus, the Rho kinase pathway may indeed be a worthwhile therapeutic target in the treatment of asthma and chronic obstructive pulmonary disease. |
| Databáze: | OpenAIRE |
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