Endocrine pancreatic tumors: factors correlated with survival
| Autor: | Francesca Nori, Donatella Santini, Davide Campana, Lydia Piscitelli, Antonio Maria Morselli-Labate, Riccardo Casadei, Roberto Corinaldesi, Raffaele Pezzilli, Paola Tomassetti |
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| Přispěvatelé: | Tomassetti P., Campana D., Piscitelli L., Casadei R., Santini D., Nori F., Morselli-Labate AM., Pezzilli R., Corinaldesi R. |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Pancreatic disease Palliative care Gastroenterology Pancreatic tumor Internal medicine Multiple Endocrine Neoplasia Type 1 medicine Humans Radical surgery Multiple endocrine neoplasia Survival rate Endocrine gland neoplasm Aged Aged 80 and over business.industry Liver Neoplasms Palliative Care Hematology Middle Aged medicine.disease Pancreatic Neoplasms Survival Rate Treatment Outcome medicine.anatomical_structure Oncology Lymphatic Metastasis Female Pancreas business |
| Zdroj: | Annals of Oncology. 16:1806-1810 |
| ISSN: | 0923-7534 |
| Popis: | Background: The aim of this study was to evaluate the survival rate of patients with endocrine tumors of the pancreas, functioning or non-functioning, associated or not with MEN 1 syndrome. Patients and methods: Eighty-three patients with pancreatic endocrine tumors diagnosed in our department from 1978 to 2003 were studied. Results: The study included 37 men (44.6%) and 46 women (55.4%). The median age of patients at diagnosis was 55 years (range 19–81 years). Fifty-two patients (62.7%) had non-functioning endocrine tumors, 16 (19.3%) had functioning endocrine tumors and 15 (18.1%) had MEN 1 disease with pancreatic involvement. Twenty-seven patients (32.5%) had liver metastases at the time of diagnosis, involvement of the lymph nodes was found in 47 out of 79 patients (59.5%). Forty patients (48.2%) had radical surgery, 20 (24.1%) had palliative surgery and 53 were treated medically. The survival rate was significantly related to the presence of metastases, lymph node involvement, and the type of tumor and treatment. Conclusions: Tumor resection, the absence of liver and lymph node metastases, and the presence of MEN 1 syndrome are related to a better survival rate. Radical surgery continues to have a central role in the therapeutic approach to endocrine tumors of the pancreas. |
| Databáze: | OpenAIRE |
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