DendroPrime as an adhesion barrier on fracture fixation plates: an experimental study in rabbits
| Autor: | Patrik Stenlund, Henrik Alfort, Viktor Granskog, Yalda Bogestål, Johanna von Kieseritzky, Daniel J. Hutchinson, Joakim Håkansson, Michael Malkoch, Marianne Arner |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
plate fixation rabbit Adhesion (medicine) engineering.material Bone and Bones Tendons Fracture Fixation Internal Fractures Bone Coating Fracture Fixation Naturvetenskap Fracture fixation Animals Medicine flexor tendon Periosteum Second toes business.industry Soft tissue Adhesion barrier medicine.disease Tendon Fracture medicine.anatomical_structure adhesion barrier engineering Full Length Articles Surgery Rabbits Natural Sciences business Bone Plates Biomedical engineering |
| Zdroj: | The Journal of Hand Surgery, European Volume |
| ISSN: | 2043-6289 1753-1934 |
| DOI: | 10.1177/1753193420932477 |
| Popis: | We tested the anti-adhesional effect of a new thiol-ene-based coating in a rabbit model. In 12 New Zealand white rabbits, the periosteum and cortex of the proximal phalanx of the second toe of both hind paws was scratched. Stainless steel plates were fixated with screws. One plate was coated with DendroPrime and the other left bare. The non-operated second toes of both hind paws of an additional four rabbits served as controls. Seven weeks after surgery, the soft tissue adhesion to the plates was evaluated macroscopically, and joint mobility was measured biomechanically. Toe joint mobility was about 20% greater and statistically significant in specimens with coated plates compared with the bare plates. Soft tissue overgrowth and, in some cases, synovitis or adhesions between the plate and the tendon were observed on all bare plates but not on any of the coated plates. We conclude that the thiol-ene-based coating can improve joint mobility by about 20%. This material has a potential to reduce adhesion around plates in fracture surgery. © The Author(s) 2020. |
| Databáze: | OpenAIRE |
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