Anabolic Actions of a Mixed β-Adrenergic Agonist on Nitrogen Retention and Protein Turnover
| Autor: | Portillo Mp, José Alfredo Martínez, J. Larralde |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Agonist medicine.medical_specialty Nitrogen balance Anabolism Nitrogen G protein medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Muscle Proteins Context (language use) Biology Biochemistry Endocrinology Internal medicine medicine Animals Metaproterenol Muscles Biochemistry (medical) Protein turnover Heart Rats Inbred Strains DNA Organ Size General Medicine Metabolism Rats Adipose Tissue RNA |
| Zdroj: | Hormone and Metabolic Research. 23:590-593 |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | Subcutaneous administration of a mixed beta-agonist induced increases in muscle (+13%) and heart (+17%) weights, which were accompanied by a reduction in back (-13%) and perirenal (-27%) fat stores in young male rats, while no changes in liver were observed. The values of nitrogen retention (mg/day) were significantly higher in the beta-agonist treated animals (+16%) as well as those of muscle DNA content (+8%). On the other hand, no statistically significant changes in muscle protein synthetic activity (g protein synthetized/g RNA) were detected (control: 13.4 vs treated: 14.6), while muscle proteolytic activity was decreased (-9%) in those rats administered with the repartitioning agent. In this context, it is suggested that the anabolic effect of metaproterenol should be attributed to a reduction in muscle protein degradation rather than to changes in protein synthesis. |
| Databáze: | OpenAIRE |
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