The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
| Autor: | Parkyong Song, Young-A Choi, Sung-Jin Heo, Chang-Hyung Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis Glucose uptake Physical exercise metabolic syndrome Rats Sprague-Dawley Adipose Tissue Brown Positron Emission Tomography Computed Tomography Internal medicine Brown adipose tissue Coactivator medicine Animals Receptor Uncoupling Protein 1 Hyperbaric Oxygenation business.industry hyperbaric treatment Brief Report Public Health Environmental and Occupational Health brown adipose tissue Peroxisome medicine.disease Thermogenin Rats Cold Temperature Endocrinology medicine.anatomical_structure Medicine Metabolic syndrome business oxygen |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 9165, p 9165 (2021) International Journal of Environmental Research and Public Health |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Brown adipose tissue (BAT) plays an important role in thermogenic regulation, which contributes to alleviating diet-induced obesity through uncoupling protein 1 (UCP1) expression. While cold exposure and physical exercise are known to increase BAT development and UCP1 expression, the contribution of hyperbaric oxygen (HBO) therapy to BAT maturation remains largely unknown. Here, we show that HBO treatment sufficiently increases BAT volumes and thermogenic protein levels in Sprague-Dawley rats. Through 18F-FDG PET/CT analysis, we found that exposure to high-pressure oxygen (1.5–2.5 ATA) for 7 consecutive days increased radiolabeled glucose uptake and BAT development to an extent comparable to cold exposure. Consistent with BAT maturation, thermogenic protein levels, such as those of UCP1 and peroxisome proliferator-activated receptor γ coactivator 1α (PGC−1α), were largely increased by HBO treatment. Taken together, we suggest HBO therapy as a novel method of inducing BAT development, considering its therapeutic potential for the treatment of metabolic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|