Influence of Spontaneous Platelet Aggregation on Progression of Glomerular Disease
| Autor: | Bolesław Rutkowski, S. Lizakowski, Zbigniew Zdrojewski, Raszeja-Specht A, Skibowska A |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Platelet Aggregation Renal function Pathogenesis chemistry.chemical_compound Glomerulonephritis Internal medicine medicine Humans Platelet Prospective Studies Spontaneous platelet aggregation Creatinine Platelet Count business.industry medicine.disease Pathophysiology Endocrinology chemistry Disease Progression Nephrosis Regression Analysis Female business Kidney disease |
| Zdroj: | Nephron. 92:36-42 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | Platelet secretion products may play an important role in the pathogenesis and progression of the kidney disease. Amongst the parameters describing platelet hyperactivity the measurement of spontaneous platelet aggregation (SPA) seems particularly useful. In this study SPA as well as mean platelet volume (MPV), modal platelet volume (PLT Mode) and platelet count (PLT) were investigated in 60 patients with biopsy proven primary glomerulonephritis. SPA was measured using the turbidimetric method according to Born with no enhancers added. Serum creatinine concentration (Cr), reciprocal serum creatinine concentration (1/Cr) and endogenous creatinine clearance (ClCr) were used for the renal function estimation. Protein and lipid profiles as well as coagulo-fibrinolytic balance were measured in parallel. The investigated group consisted of 30 non-nephrotic patients (CGN) – in 9, SPA was found (CGN-B) while 21 had SPA Cr) were noted in subgroups showing SPA. A significant correlation between SPA and ΔCr/month (r = 0.41), Δ1/Cr/month (r = 0.38) as well as ΔClCr/month (r = 0.52) was found. The platelet activity and thus SPA can be altered by various factors: albumin and fibrinogen plasma concentrations, thrombosis activation and possibly lipoprotein metabolism disturbances. A characteristic feature of spontaneously aggregating platelet is their increased volume (MPV). Conclusion: Platelet hyperaggregation in one of nonimmunological factors stimulates the progression of glomerulonephritis. |
| Databáze: | OpenAIRE |
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