A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?

Autor:	Jan G.P. Tijssen, Wilmar M. Wiersinga, Mark F. Prummel, W.K. Lam-Tse, Thea G. A. Strieder, Hemmo A. Drexhage
Přispěvatelé:	Amsterdam Cardiovascular Sciences, Cardiology, Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	Adult CD4-Positive T-Lymphocytes endocrine system medicine.medical_specialty T cell Immunology medicine.disease_cause Major histocompatibility complex Lymphocyte Activation Autoantigens Iodide Peroxidase Autoimmunity Autoimmune thyroiditis Cohort Studies Risk Factors T-Lymphocyte Subsets Internal medicine Iron-Binding Proteins medicine Immunology and Allergy Humans Euthyroid IL-2 receptor First-degree relatives Autoantibodies Autoimmune disease biology business.industry Thyroiditis Autoimmune hemic and immune systems Receptors Interleukin-2 Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Self Tolerance Case-Control Studies biology.protein Female business Biomarkers Follow-Up Studies
Zdroj:	Autoimmunity, 39(2), 93-98. Informa Healthcare
ISSN:	0891-6934
DOI:	10.1080/08916930500508092
Popis:	There is room for immune markers other than TPO-Abs to identify an increased risk to develop autoimmune thyroid disease (AITD). Our aim was to test the hypothesis that activation of CD4+ T cells is such marker in relatives of AITD patients, who have an increased risk to develop AITD. We established a controlled study on 20 TPO-Ab positive and 20 TPO-Ab negative euthyroid female relatives. All these cases had at least one 1st or 2nd degree relative with a documented autoimmune hyper- or hypothyroidism in whom we studied the percentages of circulating subsets of activated (MHC class-II, CD25 (IL-2R), CD71 or CD69+) CD4+ T cells and the level of the soluble (s)-IL2R in serum. We found that euthyroid female relatives did not show an activation of their T cell system, but a reduced expression of CD25 on CD4+ T cells. The level of the shed IL2R in serum was also lower in comparison with levels found in healthy control females. A reduced T cell activity was found in both TPO-Ab positive and negative relatives. In conclusion, female relatives with at least one 1st or 2nd degree relative with an AITD show signs of a reduced expansion capability of their T cell pool. It is hypothesized that this reduced expansion capability may affect T cell tolerance mechanisms more than T effector mechanisms.
Databáze:	OpenAIRE
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