Caspr2 autoantibody-associated Morvan syndrome predating thymoma relapse by 30 months
| Autor: | Pegah Masrori, Massimiliano Montagna, Livia De Picker, Paul Van Schil, Annelies Janssens, Jo Raskin, Rudy Mercelis, Hannah Vaesen Bentein, Ilse De Volder |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Male Cancer Research medicine.medical_specialty Thymoma Lung Neoplasms Ocular myasthenia Central nervous system medicine.disease_cause Gastroenterology Autoimmunity 03 medical and health sciences 0302 clinical medicine Peripheral nerve Internal medicine medicine Humans Autoantibodies Sleep disorder business.industry Autoantibody Thymus Neoplasms medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Human medicine Neoplasm Recurrence Local business Encephalitis |
| Zdroj: | Lung cancer: journal of the International Association for the Study of Lung Cancer |
| ISSN: | 1872-8332 0169-5002 |
| Popis: | Morvan's syndrome (MoS) is a rare autoimmune disorder characterized by central nervous system involvement, autonomic dysfunction and peripheral nerve hyperexcitability. MoS is believed to be caused by autoantibodies targeting contactin-associated protein 2 (Caspr2), a subunit of the neuronal voltage-gated potassium channel (VGKC) complex, usually in association with thymoma, less commonly with other malignancies. This case highlights an exceptional case of severe sleep disturbances and behavioural changes due to MoS, in a patient who would present with and be treated successfully for a second relapse of thymoma 30 months later. Originally he suffered from ocular myasthenia, another autoimmune disorder, which led to diagnosis of his original thymoma and first relapse. |
| Databáze: | OpenAIRE |
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