The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice
| Autor: | Gunnar Hargus, Andrey Irintchev, Meifang Xiao, Igor Jakovcevski, Elena Sivukhina, Jinchong Xu, Melitta Schachner, Yi Fang Cui, Christian Bernreuther |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Neurogenesis
Embryonic Development Biology Hippocampal formation Inhibitory postsynaptic potential Hippocampus Mice Animals Tenascin-R Progenitor cell Molecular Biology Cell Proliferation Neurons Stem Cells Dentate gyrus Gene Expression Regulation Developmental Cell Differentiation Tenascin Cell Biology Embryo Mammalian Neural stem cell Extracellular Matrix Cell biology ASCL1 nervous system Dentate Gyrus Immunology GABAergic Developmental Biology |
| Zdroj: | Journal of Cell Science. |
| ISSN: | 1477-9137 0021-9533 |
| DOI: | 10.1242/jcs.137612 |
| Popis: | Abnormal generation of inhibitory γ-aminobutyric acid synthesizing (GABAergic) neurons is characteristic of neuropsychological disorders. We provide evidence that the extracellular matrix molecule tenascin-R (TNR) – being predominantly expressed, among neurons, by subpopulation of interneurons - plays a role in the generation of GABAergic and granule neurons in the murine dentate gyrus by regulating fate determination of neural stem/progenitor cells (NSCs). During development, absence of TNR in constitutively TNR-deficient (TNR−/−) mice results in increased numbers of dentate gyrus GABAergic neurons, being associated with decreased expression of its receptor β1 integrin, increased activation of p38 MAPK, and increased expression of the GABAergic specification gene ASCL1. Postnatally, increased GABAergic input to adult hippocampal NSCs in TNR−/− mice is associated not only with increased numbers of GABAergic and, particularly, parvalbumin-immunoreactive neurons, as seen during development, but also with increased numbers of granule neurons, thus contributing to the increased differentiation of NSCs into granule cells. These findings indicate the importance of TNR in the regulation of hippocampal neurogenesis and suggest that TNR acts through distinct direct and indirect mechanisms during development and in the adult. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|