High serum oxytocin is associated with metabolic syndrome in older men - The MINOS study
| Autor: | Ez-Zoubir Amri, Annie Varennes, Eric Fontas, Roland Chapurlat, Véronique Breuil, Pawel Szulc, Patricia Panaia-Ferrari, Joëlle Goudable |
|---|---|
| Přispěvatelé: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism [SDV]Life Sciences [q-bio] Osteocalcin 030209 endocrinology & metabolism Oxytocin Cohort Studies Excretion 03 medical and health sciences 0302 clinical medicine Endocrinology Surveys and Questionnaires Internal medicine Diabetes mellitus Internal Medicine Humans Medicine Prospective Studies Volunteer Abdominal obesity Testosterone Aged Aged 80 and over Metabolic Syndrome 2. Zero hunger business.industry General Medicine Middle Aged medicine.disease Cross-Sectional Studies Cohort Body Composition medicine.symptom Metabolic syndrome business 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Diabetes Research and Clinical Practice Diabetes Research and Clinical Practice, Elsevier, 2016, 122, pp.17-27. ⟨10.1016/j.diabres.2016.09.022⟩ |
| ISSN: | 0168-8227 |
| Popis: | International audience; AIM: Oxytocin regulates food intake, carbohydrate and lipid metabolism, and urinary sodium excretion. We assessed the association between serum oxytocin levels and presence of metabolic syndrome (MetS) in older men. METHODS: Cross-sectional study was performed in 540 volunteer men aged 50-85yrs from the MINOS cohort. Oxytocin was measured in fasting serum by radioimmunoassay (Oxytocin RIA, Phoenix Pharmaceuticals). MetS was diagnosed using the harmonized definition. RESULTS: Serum oxytocin was higher in 166 men with MetS vs. controls (p\textless0.005). After adjustment for confounders including leptin, higher oxytocin was associated with higher odds of MetS (OR=1.38 per SD, 95%CI: 1.10-1.71, p\textless0.005). Men with serum oxytocin \textgreater0.74pg/mL (median) had higher odds of MetS vs. men with oxytocin 0.74pg/mL (OR=2.06, 95%CI: 1.33-3.18, p\textless0.005). Higher oxytocin levels and low testosterone levels (total or free) were significantly associated with higher odds of MetS jointly and independently of each other. Men having oxytocin \textgreater0.74pg/mL and total testosterone \textless300ng/dL (\textless10.4nmol/L) had higher odds of MetS vs. men without these characteristics (OR=3.95, 95%CI: 1.65-9.46, p\textless0.005). Men having 25-hydroxycholecalciferol levels \textless30ng/mL and oxytocin \textgreater0.74pg/mL had higher odds of MetS vs. men without these characteristics (OR=2.86, 95%CI: 1.47-5.58, p\textless0.01). Men having oxytocin \textgreater0.74pg/mL and osteocalcin levels \textless14.6ng/mL (lowest quartile) had higher odds of MetS vs. men without these characteristics (OR=4.12, 95%CI: 2.07-8.20, p\textless0.001). CONCLUSION: In older men, higher serum oxytocin levels are associated with higher odds of MetS regardless of potential confounders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect