Association Between Lipoprotein Particles and Atherosclerotic Events in Nonalcoholic Fatty Liver Disease
| Autor: | Michael O. Idowu, Emily Lee, Velimir A. Luketic, Jose A. Hernandez Roman, Arun J. Sanyal, Emily Zhang, Steve Shen, Mohammad Bilal Siddiqui, Robert J. Mintini, Masoud Faridnia, Samarth Patel, Sherry Boyett, Mohammad S. Siddiqui |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Statin medicine.drug_class Lipoproteins Disease Chronic liver disease Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Nonalcoholic fatty liver disease medicine Humans Prospective Studies Prospective cohort study Hepatology medicine.diagnostic_test business.industry nutritional and metabolic diseases Atherosclerosis medicine.disease digestive system diseases Residual risk Cross-Sectional Studies Cardiovascular Diseases 030220 oncology & carcinogenesis lipids (amino acids peptides and proteins) 030211 gastroenterology & hepatology Lipid profile business Lipoprotein |
| Zdroj: | Clin Gastroenterol Hepatol |
| ISSN: | 1542-3565 |
| DOI: | 10.1016/j.cgh.2020.09.039 |
| Popis: | Nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease,1 is independently associated with increased risk of cardiovascular disease (CVD), which is the leading cause of mortality in patients with NAFLD.2 This is likely caused by the centrality of the liver in lipid homeostasis. Prior cross-sectional studies have shown that NAFLD is associated with perturbations in lipid profile and atherogenic lipoprotein subparticles.3 Although statins improve lipid profile and CVD-associated mortality, residual CVD risk has been demonstrated in major statin trials.4,5 A key contributor to this residual risk is the limited ability of the standard lipid profile to precisely quantify atherogenic lipoprotein subparticles, such as small dense low-density lipoprotein (sdLDL), which might confer higher atherogenic risk. There are currently no studies evaluating the longitudinal impact of sdLDL on atherosclerotic events in NAFLD. Thus, we conducted a prospective study in patients with histologically confirmed NAFLD to better define the relationship among NAFLD, residual CVD risk, and sdLDL. |
| Databáze: | OpenAIRE |
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