Molecular Pathology of Meningiomas
| Autor: | Tibor Hortobágyi, Tamás Csonka, Balázs Murnyák |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty Poor prognosis Pathology Loss of Heterozygosity Epigenesis Genetic Meningioma Risk Factors Internal medicine Meningeal Neoplasms otorhinolaryngologic diseases medicine Humans Meningeal Neoplasm Epigenetics Pathology Molecular neoplasms Neoplasm Grading Brain Neoplasms Molecular pathology business.industry DNA Methylation Prognosis medicine.disease nervous system diseases Tumor recurrence Gene Expression Regulation Neoplastic MicroRNAs Neurology Mutation Benign Meningioma CpG Islands Neurology (clinical) Neoplasm Recurrence Local business Genes Neoplasm |
| Zdroj: | Ideggyógyászati szemle. 68:292-300 |
| ISSN: | 0019-1442 |
| Popis: | Meningiomas represent nearly one-third of all adult primary brain tumours. According to their clinical and histologic appearance, they can be divided into WHO grades I-III. Almost 90% of meningiomas are benign, showing favourable response to conventional therapies, however, patients diagnosed with grade 2 and 3 tumours may have a poor prognosis. In addition, high frequency of tumour recurrence renders treatments more challenging even in benign meningiomas. Molecular-pathological profiling of meningiomas could lead to development of more effective therapies. Although the cytogenetic background of these tumours are already well-characterised, the majority of related genes and mutations is still unknown. Recently, high-throughput techniques enabled better characterisation of mechanisms involved in meningioma development, progression and recurrence. Furthermore, epigenetic dysregulation could offer new opportunities for both diagnosis and treatment of meningiomas. We provide a comprehensive overview of cytogenetic and molecular genetic defects as well as epigenetic alterations in meningiomas. Many of these may serve as biomarker or therapeutic target in the near future. |
| Databáze: | OpenAIRE |
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