No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients
Autor: | Xu Li, Yufeng Gao, Fang Yan, Feng Lv, Tian-Chen Zhang, Hua-Fa Yin |
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Rok vydání: | 2011 |
Předmět: |
Adult
Male Genotype Brief Article viruses Single-nucleotide polymorphism Biology medicine.disease_cause Polymorphism Single Nucleotide Hepatitis B Chronic Asian People Gene Frequency medicine Humans Allele Allele frequency Hepatitis B virus Haplotype Gastroenterology virus diseases General Medicine Odds ratio Hepatitis B medicine.disease Case-Control Studies Immunology Female Interferon Regulatory Factor-3 Disease Susceptibility |
Zdroj: | World journal of gastroenterology. 18(4) |
ISSN: | 2219-2840 |
Popis: | AIM: To investigate the association between three tag single nucleotide polymorphisms (tagSNPs) in interferon regulatory factors (IRF3) and the genetic susceptibility to chronic hepatitis B virus (HBV) infection. METHODS: We performed a case-control study of 985 Chinese cases of chronic HBV infection and 294 self-limiting HBV-infected individuals as controls. Three tagSNPs in IRF3 (rs10415576, rs2304204, rs2304206) were genotyped with the Multiplex SNaPshot technique. The genotype and allele frequencies were calculated and analyzed. RESULTS: The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were: rs10415576, P = 0.0908, odds ratio (OR) [95% confidence interval (CI)] = 1.1798 (0.9740-1.4291); rs2304204, P = 0.5959, OR (95% CI) = 1.0597 (0.8552-1.3133); rs2304206, P = 0.8372, OR (95% CI) = 1.0250 (0.8097-1.2976). Overall genotype P values were: rs10415576, P = 0.2106; rs2304204, P = 0.8458; rs2304206, P = 0.8315. There were no statistically significant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs were also not significantly different between the two groups. CONCLUSION: The three tagSNPs of IRF3 are not associated with HBV infection in the Han Chinese population. |
Databáze: | OpenAIRE |
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