Hydroxyproline in the Early Diagnosis of Bone Metastases in Prostatic Cancer
| Autor: | Eero A. Sotaniemi, Matti Kontturi, T. K. I. Larmi |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.drug_class Urology Administration Oral Bone Neoplasms Urine Elevated serum Excretion Hydroxyproline chemistry.chemical_compound Internal medicine Methods medicine Humans Neoplasm Metastasis Diethylstilbestrol Normal range Aged business.industry Prostatic Neoplasms Cancer Middle Aged medicine.disease Androgen Normal limit Phosphoric Monoester Hydrolases Radiography Endocrinology chemistry Neoplasm Regression Spontaneous Nephrology Injections Intravenous Strontium Radioisotopes business |
| Zdroj: | Scandinavian Journal of Urology and Nephrology. 8:91-95 |
| ISSN: | 1651-2065 0036-5599 |
| DOI: | 10.3109/00365597409132111 |
| Popis: | The usefulness of hydroxyproline assays in the early diagnosis of bone metastases was investigated in 26 prostatic cancer patients. Patients with bone metastases detectable by the conventional X-ray technique or by radiostrontium had significantly higher mean serum hydroxyproline values, and they also excreted significantly more hydroxyproline in the urine than the patients without metastases. The patients for whom the external counting with radiostrontium showed metastases, but whose X-ray findings were negative, had elevated serum hydroxyproline values, while the excretion of hydroxyproline and the serum phosphatase concentrations ranged within the normal limits. Patients without metastases had normal serum hydroxyproline values, and their excretion similarly vaned in the normal range. After the introduction of androgen control therapy, the elevated values of hydroxyproline and serum phosphatases became normalized simultaneously over a period of 4 months. The results indicate that serum hydroxyproline a... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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