High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis

Autor: Jürg A. Schifferli, Véronique Frémeaux-Bacchi, Mari Luz Picazo, Margarita López-Trascasa, Marten Trendelenburg, Eliska Potlukova, Stephan Regenass, Solange Moll, Eva Honsova, Vladimir Tesar, Jorge Martínez-Ara, Eva Jancova, Salima Sadallah
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Adult
Male
Lupus nephritis
Complement C1q/immunology
chemical and pharmacologic phenomena
ddc:616.07
Kidney
urologic and male genital diseases
Lupus Erythematosus
Systemic/diagnosis/immunology/pathology
fluids and secretions
Kidney/pathology
immune system diseases
Biopsy
medicine
Prevalence
Lupus Erythematosus
Systemic
Humans
Prospective Studies
skin and connective tissue diseases
Autoantibodies
Aged
Transplantation
Lupus erythematosus
Systemic lupus erythematosus
medicine.diagnostic_test
Autoantibodies/blood
Lupus Erythematosus
Systemic/diagnosis
Lupus Erythematosus
Systemic/immunology
Lupus Erythematosus
Systemic/pathology
Lupus Nephritis/diagnosis
Lupus Nephritis/immunology
Lupus Nephritis/pathology
business.industry
Complement C1q
Autoantibody
Lupus Nephritis/diagnosis/immunology/pathology
Middle Aged
medicine.disease
Lupus Nephritis
Nephrology
Immunology
Female
Renal biopsy
business
Nephritis
Kidney disease
Follow-Up Studies
Zdroj: Nephrology, Dialysis, Transplantation, Vol. 21, No 11 (2006) pp. 3115-21
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association-European Renal Association, vol. 21, no. 11, pp. 3115-3121
ISSN: 0931-0509
Popis: BACKGROUND: Anti-C1q antibodies (anti-C1q) have been shown to correlate positively with systemic lupus erythematosus (SLE) nephritis. Several clinical studies indicated a high negative predictive value, suggesting that active lupus nephritis is rarely seen in patients with no anti-C1q. However, the true prevalence of anti-C1q at the time of active lupus nephritis has not been well established. The aim of this study was to determine prospectively the prevalence of anti-C1q in proven active lupus nephritis at the time of the renal biopsy. METHODS: In this prospective multi-centre study, we investigated adult SLE patients undergoing renal biopsy for suspected active lupus nephritis. Serum samples were taken at the time of the biopsy and analysed for the presence of anti-C1q in a standardized way. The activity of lupus nephritis was classified according to the renal histology. Biopsies were also analysed for the presence of glomerular IgG, C1q and C3 deposition. RESULTS: A total of 38 patients fulfilling at least 4/11 American College of Rheumatology (ACR) criteria for the diagnosis of SLE were included. Out of this, 36 patients had proliferative (class II, III or IV) and two had class V lupus nephritis. All but one patient with proliferative lupus nephritis were positive for anti-C1q (97.2%) compared with the 35% of control SLE patients with inactive lupus nephritis and 25% of SLE patients without lupus nephritis ever. All patients were positive for glomerular C1q (36/36) and 37/38 patients had glomerular IgG deposits. Anti-C1q strongly decreased during successful treatment. CONCLUSIONS: Anti-C1q have a very high prevalence in biopsy-proven active lupus nephritis, thus a negative test result almost excludes active nephritis. The data support the hypothesis of a pathogenic role of anti-C1q in lupus nephritis.
Databáze: OpenAIRE
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