Supplemental Figures 1-6 from Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer

Autor: Khandan Keyomarsi, Kelly K. Hunt, Mark J. McArthur, Smruthi Vijayaraghavan, Dong Yang, Yufeng Jiang, Tuyen Bui, Xian Chen, Natalie A. Jabbour-Leung
Rok vydání: 2023
DOI: 10.1158/1535-7163.22508811.v1
Popis: Six supplemental Figures are included in this file. The figure titles are as follows: Supplemental Figure 1. Changes in G2/M cell cycle phase following treatment as a function of receptor status. Supplemental Figure 2. Downreguation of CDK1, CDK2 or both in ER positive cells. Supplemental Figure 3. Cell cycle analysis following single or combination treatments. Supplemental Figure 4. Sequential combination treatment of roscovitine and doxorubicin causes more DNA double strand breaks in p53 mutant in colon cancer cells. . Supplemental Figure 5. Sequential roscovitine-doxorubicin combination treatment is effective and well tolerated in vivo. Supplemental Figure 6 Dose escalation of doxorubicin in vivo
Databáze: OpenAIRE