Antimetastatic effect of desmopressin in a mouse mammary tumor model
| Autor: | Daniel F. Alonso, Eduardo F. Farías, Elisa Bal de Kier Joffé, Daniel E. Gomez, Guillermo Skilton |
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| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
medicine.medical_specialty Vasopressin Lung Neoplasms Mammary gland urologic and male genital diseases Hemostatics Metastasis Mice Circulating tumor cell In vivo Internal medicine medicine Animals Cytotoxic T cell Deamino Arginine Vasopressin Cell Aggregation Mice Inbred BALB C Mammary tumor business.industry Mammary Neoplasms Experimental medicine.disease Endocrinology medicine.anatomical_structure Oncology Cancer research Adenocarcinoma Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Breast Cancer Research and Treatment. 57:271-275 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1023/a:1006291607871 |
| Popis: | We have investigated the effects of desmopressin (DDAVP), a synthetic analog of the natural hormone vasopressin, on experimental lung colonization of mammary tumor cells using a syngeneic BALB/c mouse model. Coinjection of DDAVP (1-2 microg/kg body weight) at the time of i.v. inoculation of F3II carcinoma cells or LM3 adenocarcinoma cells significantly inhibited the formation of experimental lung metastases. In both cases, the number of pulmonary nodules was reduced about 70%. Inhibition of metastasis was also obtained with i.v. administration of DDAVP 24 h after tumor cell inoculation. Interestingly, the inhibition of lung metastasis was not due to direct cytotoxic effects of DDAVP on mammary tumor cells. The in vitro formation of multicellular aggregates in the presence of citrated plasma from control and DDAVP-treated mice was also examined. Control plasma rapidly induced a significant tumor cell aggregation. In contrast, in the presence of plasma from DDAVP-treated mice, tumor cells remained as a single cell suspension. DDAVP may help to dissolve the protective fibrin shield of circulating tumor cells. Our data suggest, for the first time, that adjuvant DDAVP therapy may impair successful implantation of circulating mammary tumor cells. |
| Databáze: | OpenAIRE |
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