Toxicological studies on metoprolol *
| Autor: | T. Malmfors, H. Flodh, Jan-Anders Nyberg, Göran Magnusson, Nils-Olof Bodin |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Acute effects Single administration Administration Oral Pharmacology Toxicology Median lethal dose Lethal Dose 50 Propanolamines Mice Dogs Pregnancy High doses Animals Medicine Metoprolol business.industry Phenyl Ethers Reproduction Teratology Rats Fertility Maximum tolerated dose Injections Intravenous Female Rabbits business medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 36:96-103 |
| ISSN: | 0001-6683 |
| Popis: | This paper presents a review of the toxicological studies in animals on metoprolol - a cardioselective β-blocking agent. Studies after single administration were performed in mice, rats and dogs. LD50-values were calculated for the rodents while maximum tolerated dose was estimated for the dogs. Studies after repeated administration for up to 6 months were performed in rats and dogs. Reproduction studies were performed in rats and rabbits. The studies performed on metoprolol so far have not revealed any toxic effect other than the acute effects observed after administration of single, high doses. |
| Databáze: | OpenAIRE |
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