A comparative study of intravenous and rectal administration of propofol in piglets
| Autor: | P. H. Rosenberg, K. Levonen, M. Sandholm, D. A. Cozanitis, M. Marvola |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Volume of distribution Swine business.industry Biological Availability General Medicine Intravenous anaesthesia Dosage form Bioavailability Anesthesiology and Pain Medicine Pharmacokinetics Administration Rectal Anesthesia Rectal administration Injections Intravenous Time course Animals Medicine Female business Propofol medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 35:575-577 |
| ISSN: | 1399-6576 0001-5172 |
| Popis: | To compare the effectiveness of propofol given intravenously and rectally, ten piglets received propofol intravenously. On the next day, the same piglets and five other piglets were given suppositories containing propofol. Serial blood samples were collected for the analysis of propofol plasma concentration. The time course of the total plasma drug concentration was fitted into a bi-exponential function using a least square fitting regression computer programme. The volume of distribution was 2.5-2.8 l.kg-1, mean elimination half-life, 23.9 min and mean clearance 0.08 l.kg-1.min-1. The mean bioavailability by the rectal route was low. In contrast to the intravenously administered propofol, none of the piglets slept when given propofol rectally, reflecting the extremely low plasma propofol concentration. In veterinary medicine, propofol would seem to be clinically valuable for inducing intravenous anaesthesia, but would be ineffective when given rectally. The findings indicate that with the dosage forms used here, propofol would be clinically ineffective if given rectally to human infants and children. |
| Databáze: | OpenAIRE |
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