Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages
| Autor: | Philippe, Abdel-Sayed, Ariane, Kaeppeli, Ariane, Kaeppli, Thissa, Siriwardena, Tamis, Darbre, Karl, Perron, Paris, Jafari, Jean-Louis, Reymond, Dominique P, Pioletti, Lee Ann, Applegate |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Dendrimers Angiogenesis Cell Survival Neovascularization Physiologic 02 engineering and technology Pharmacology Biology medicine.disease_cause Article Neovascularization 03 medical and health sciences Anti-Infective Agents 540 Chemistry medicine Humans Viability assay Wound Healing ddc:615 Multidisciplinary Pseudomonas aeruginosa Fibroblasts Angiogenesis Inducing Agents/pharmacology Anti-Infective Agents/pharmacology Bandages Burns/complications Cell Survival/drug effects Fibroblasts/drug effects Fibroblasts/metabolism Neovascularization Physiologic/drug effects Pseudomonas aeruginosa/drug effects Wound Infection/drug therapy Wound Infection/microbiology 021001 nanoscience & nanotechnology Antimicrobial Corrigenda 3. Good health Surgery Multiple drug resistance 030104 developmental biology ddc:580 Wound Infection 570 Life sciences biology Angiogenesis Inducing Agents medicine.symptom 0210 nano-technology Wound healing Burns |
| Zdroj: | Scientific Reports, Vol. 6 (2016) P. 22020 Scientific Reports Scientific reports, vol. 6, pp. 22020 Abdel-Sayed, Philippe; Kaeppli, Ariane; Siriwardena, Thissa; Darbre, Tamis; Perron, Karl; Jafari, Paris; Reymond, Jean-Louis; Pioletti, Dominique P.; Applegate, Lee Ann (2016). Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages. Scientific Reports, 6(22020), p. 22020. Nature Publishing Group 10.1038/srep22020 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep22020 |
| Popis: | Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with significant morbidity and costs. Anti-microbial polycationic dendrimers G3KL and G3RL, able to kill multi-drug resistant P. aeruginosa, have been previously developed. The combination of these dendrimers with a class of biological bandages made of progenitor skin cells, which secrete growth factors, could positively impact wound-healing processes. However, polycations are known to be used as anti-angiogenic agents for tumor suppression. Since, neovascularization is pivotal in the healing of deep burn-wounds, the use of anti-microbial dendrimers may thus hinder the healing processes. Surprisingly, we have seen in this study that G3KL and G3RL dendrimers can have angiogenic effects. Moreover, we have shown that a dendrimer concentration ranging between 50 and 100 μg/mL in combination with the biological bandages can suppress bacterial growth without altering cell viability up to 5 days. These results show that antimicrobial dendrimers can be used in combination with biological bandages and could potentially improve the healing process with an enhanced angiogenesis. |
| Databáze: | OpenAIRE |
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