Increased Impulsivity Retards the Transition to Dorsolateral Striatal Dopamine Control of Cocaine Seeking
| Autor: | Yann Pelloux, Jennifer E. Murray, David Belin, Daina Economidou, Barry J. Everitt, Jeffrey W. Dalley, Ruth Dilleen |
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| Rok vydání: | 2014 |
| Předmět: |
Male
drug addiction medicine.medical_specialty Microinjections striatum media_common.quotation_subject Drug-Seeking Behavior Self Administration Striatum goal-directed Impulsivity Choice Behavior 03 medical and health sciences 0302 clinical medicine Cocaine Dopamine habitual Internal medicine medicine Animals Psychiatry Reinforcement Biological Psychiatry 030304 developmental biology media_common 0303 health sciences Dose-Response Relationship Drug Dopaminergic Neurons Addiction Dopaminergic Classical conditioning Corpus Striatum Rats Archival Report Flupenthixol Endocrinology Impulsive Behavior Dopamine Antagonists dopamine medicine.symptom Psychology Self-administration Reinforcement Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Biological Psychiatry |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2013.09.011 |
| Popis: | Background Development of maladaptive drug-seeking habits occurs in conjunction with a ventral-to-dorsal striatal shift in dopaminergic control over behavior. Although these habits readily develop as drug use continues, high impulsivity predicts loss of control over drug seeking and taking. However, whether impulsivity facilitates the transition to dorsolateral striatum (DLS) dopamine-dependent cocaine-seeking habits or whether impulsivity and cocaine-induced intrastriatal shifts are additive processes is unknown. Methods High- and low-impulsive rats identified in the five-choice serial reaction-time task were trained to self-administer cocaine (.25 mg/infusion) with infusions occurring in the presence of a cue-light conditioned stimulus. Dopamine transmission was blocked in the DLS after three stages of training: early, transition, and late-stage, by bilateral intracranial infusions of α-flupenthixol (0, 5, 10, or 15 μg/side) during 15-min cocaine-seeking test sessions in which each response was reinforced by a cocaine-associated conditioned stimulus presentation. Results In early-stage tests, neither group was affected by DLS dopamine receptor blockade. In transition-stage tests, low-impulsive rats showed a significant dose-dependent reduction in cocaine seeking, whereas high-impulsive rats were still unaffected by α-flupenthixol infusions. In the final, late-stage seeking test, both groups showed dose-dependent sensitivity to dopamine receptor blockade. Conclusions The results demonstrate that high impulsivity is associated with a delayed transition to DLS-dopamine-dependent control over cocaine seeking. This suggests that, if impulsivity confers an increased propensity to addiction, it is not simply through a more rapid development of habits but instead through interacting corticostriatal and striato-striatal processes that result ultimately in maladaptive drug-seeking habits. |
| Databáze: | OpenAIRE |
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