The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating
| Autor: | Roger L. Clem, Kirstie A. Cummings, Lingxuan Chen, Tristan Shuman, Denise J. Cai, William Mau, Sima Rabinowitz, Yosif Zaki, Zhe Dong |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Neurons
Flexibility (engineering) Neuronal Plasticity Quantitative Biology::Neurons and Cognition Consolidation (soil) Computer science Cognitive Neuroscience 05 social sciences Process (computing) Brain Experimental and Cognitive Psychology Article 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Memory Synaptic plasticity Animals Learning 0501 psychology and cognitive sciences Memory consolidation Neuroscience 030217 neurology & neurosurgery Memory Consolidation |
| Zdroj: | Neurobiol Learn Mem |
| ISSN: | 1074-7427 |
| DOI: | 10.1016/j.nlm.2020.107266 |
| Popis: | Memory is a dynamic process that is continuously regulated by both synaptic and intrinsic neural mechanisms. While numerous studies have shown that synaptic plasticity is important in various types and phases of learning and memory, neuronal intrinsic excitability has received relatively less attention, especially regarding the dynamic nature of memory. In this review, we present evidence demonstrating the importance of intrinsic excitability in memory allocation, consolidation, and updating. We also consider the intricate interaction between intrinsic excitability and synaptic plasticity in shaping memory, supporting both memory stability and flexibility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect