Systems biology approach to study the high altitude adaptation in tibetans

Autor:	Zhou Jun, Deng Xiaoyan, Liu Xiaopeng, Bi De, Xiao Huajun, Zhou Cuihong
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Genetics Multidisciplinary microRNA Systems biology lcsh:Biotechnology high-altitude adaptation systems biology Computational biology Pathway enrichment Biology single nucleotide polymorphism lcsh:TP248.13-248.65 Adaptation Function (biology) Tibetan
Zdroj:	Brazilian Archives of Biology and Technology, Vol 56, Iss 1, Pp 53-60 (2013) Brazilian Archives of Biology and Technology v.56 n.1 2013 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR Brazilian Archives of Biology and Technology, Volume: 56, Issue: 1, Pages: 53-60, Published: FEB 2013
ISSN:	1678-4324 1516-8913
Popis:	The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a270d5f706dcbbb425ad256633bb756 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007 Zobrazit plný text záznamu