Primipaternities and human birthweights

Autor: Marco Scioscia, Gustaaf A. Dekker, Gérard Chaouat, Malik Boukerrou, Pierre-Yves Robillard
Rok vydání: 2021
Předmět:
Zdroj: Journal of reproductive immunology. 147
ISSN: 1872-7603
2001-2020
Popis: To investigate in singleton multiparous pregnancies the effect of having a new father for an index pregnancy on new-borns' birthweights and intrauterine growth restriction.20 year-observational cohort study (2001-2020).Centre Hospitalier Universitaire Hospitalier Sud Reunion's maternity (French overseas department, Indian Ocean).Comparing the 811 multiparas (cases) who had a new partner with the 49,712 who did not (controls), there were no differences concerning maternal age, education, ovulation induction/IVF, previous miscarriages, exams during pregnancies, pre-pregnancy BMI, gestational diabetes, and chronic hypertension. Cases had more previous pregnancies than controls (gravidity 4.2 vs 2.8, p 0.001), volunteer abortions (OR1.93, p 0.001), in vitro fecundations (OR 4.34, p 0.001), were more likely to be unmarried (OR 2.94, p 0.001) smoker (OR 2.2, p 0.0001) and consuming alcohol during pregnancy (OR 2.35, p = 0.001). Cases had a much higher risk of preeclampsia than controls (OR 3.94, p 0.001), especially early-onset preeclampsia (34 weeks) with an OR 4.1 (p 0.001). Controlling for confounding factors (preeclampsia, smoking, alcohol use, early prematurity33 weeks, maternal ethnicity), primipaternity was an independent factor for small for gestational age newborns (OR 1.48, p 0.001).It has been known for decades that primiparas have lighter babies than multiparas. Primipaternity represents also a risk for lower birth weights. Human birthweight seems to be linked with a "couple habituation" (to paternal genes) which may be not fully established in the first pregnancy of the couple.
Databáze: OpenAIRE
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